Fungal Transcription Factor Database
Detalied information of TF Family
Detailed information of TF Family
TF family name
Heat shock factor (HSF)-type, DNA-bindingDesription
Heat shock factor (HSF) is a transcriptional activator of heat shock genes : it binds specifically to heat shock promoter elements, which are palindromic sequences rich with repetitive purine and pyrimidine motifs. Under normal conditions, HSF is a homo-trimeric cytoplasmic protein, but heat shock activation results in relocalisation to the nucleus. Each HSF monomer contains one C-terminal and three N-terminal leucine zipper repeats. Point mutations in these regions result in disruption of cellular localisation, rendering the protein constitutively nuclear. Two sequences flanking the N-terminal zippers fit the consensus of a bi- partite nuclear localisation signal (NLS). Interaction between the N- and C-terminal zippers may result in a structure that masks the NLS sequences: following activation of HSF, these may then be unmasked, resulting in relocalisation of the protein to the nucleus. The DNA-binding component of HSF lies to the N-terminus of the first NLS region, and is referred to as the HSF domain.Criteria
There is no defined InterPro Term for selection creteria.# of TFs
3 TFs in 4 Fusarium speciesReferences
5 reference(s) found in this TF familySubcellular localization
PSORT2: 0 (0.00 %)pTARGET: 0 (0.00 %)
List for Subcellular information