Fungal Transcription Factor Database
Detalied information of reference
Pubmed ID (PMID)
1549471
Paper type
Title
Evolutionary variation of the CCAAT-binding transcription factor NF-Y.
Abstract
NF-Y is a CCAAT-specific transcription factor thought to be involved in the regulation of a variety of eukaryotic genes. It shows a striking sequence similarity with the yeast factor HAP2/3. In an attempt to trace back its evolutionary history, we succeeded in isolating NF-Y cDNA clones from a plant and from several species of vertebrates. The patterns of sequence conservation delineate potential functional domains: A central, highly conserved, domain likely responsible for DNA-binding and subunit interaction; more evolutionarily flexible flanking regions, in which variability is clustered, individualizing conserved glutamine or acidic amino-acids putatively involved in protein-protein contacts.
Authors
Li XY, Mantovani R, Hooft van Huijsduijnen R, Andre I, Benoist C, Mathis D.
Affiliation
Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS, Unité 184 de Biologie Moléculaire et de Génie Génétique de I'INSERM, Institut de Chimie Biologique, Faculté de Médecine, Strasbourg, France.
Journal / Pages
Nucleic acids research., 1992 : 20(5), 1087~1091