Fungal Transcription Factor Database
Detalied information of reference
Pubmed ID (PMID)
10679470
Paper type
Title
Winged helix proteins.
Abstract
The winged helix proteins constitute a subfamily within the large ensemble of helix-turn-helix proteins. Since the discovery of the winged helix/fork head motif in 1993, a large number of topologically related proteins with diverse biological functions have been characterized by X-ray crystallography and solution NMR spectroscopy. Recently, a winged helix transcription factor (RFX1) was shown to bind DNA using unprecedented interactions between one of its eponymous wings and the major groove. This surprising observation suggests that the winged helix proteins can be subdivided into at least two classes with radically different modes of DNA recognition.
Authors
Gajiwala KS, Burley SK.
Affiliation
Laboratories of Molecular Biophysics, The Rockefeller University, New York, NY 10021, USA.
Journal / Pages
Current opinion in structural biology., 2000 : 10(1), 110~116